烟碱受体调控下的执行与社会行为
Executive and social behaviors under nicotinic receptor regulation.
作者信息
Granon Sylvie, Faure Philippe, Changeux Jean-Pierre
机构信息
Department of Neuroscience, Receptors and Cognition (Centre National de la Recherche Scientifique 2182), Institut Pasteur, 25 Rue du Dr. Roux, 75724 Paris Cedex 15, France.
出版信息
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9596-601. doi: 10.1073/pnas.1533498100. Epub 2003 Jul 22.
Abstract
Nicotine enhances several cognitive and psychomotor behaviors, and nicotinic antagonists cause impairments in tasks requiring cognitive effort. To explore the contribution of nicotinic receptors to complex cognitive functions, we developed an automated method to investigate sequential locomotor behavior in the mouse and an analysis of social behavior. We show that, in the beta2-/- mutant, the high-order spatiotemporal organization of locomotor behavior, together with conflict resolution and social interaction, is selectively dissociated from low-level, more automatic motor behaviors. Such deficits in executive functions resemble the rigid and asocial behavior found in some psychopathological disorders such as autism and attention deficit hyperactivity disorder.
摘要
尼古丁可增强多种认知和精神运动行为，而烟碱拮抗剂会导致在需要认知努力的任务中出现功能障碍。为了探究烟碱受体对复杂认知功能的作用，我们开发了一种自动化方法来研究小鼠的连续运动行为以及社交行为分析。我们发现，在β2基因敲除突变体中，运动行为的高阶时空组织以及冲突解决和社交互动与低水平、更自动的运动行为选择性分离。这些执行功能缺陷类似于在某些精神病理障碍（如自闭症和注意力缺陷多动障碍）中发现的刻板和社交障碍行为。
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