Department of Life Science, Yeungnam University, Gyeongsan-si, South Korea.
Transl Psychiatry. 2024 Apr 11;14(1):187. doi: 10.1038/s41398-024-02893-0.
Attention-deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder affecting both children and adolescents. Individuals with ADHD experience heterogeneous problems, such as difficulty in attention, behavioral hyperactivity, and impulsivity. Recent studies have shown that complex genetic factors play a role in attention-deficit hyperactivity disorders. Animal models with clear hereditary traits are crucial for studying the molecular, biological, and brain circuit mechanisms underlying ADHD. Owing to their well-managed genetic origins and the relative simplicity with which the function of neuronal circuits is clearly established, models of mice can help learn the mechanisms involved in ADHD. Therefore, in this review, we highlighting the important genetic animal models that can be used to study ADHD.
注意缺陷多动障碍（ADHD）是一种影响儿童和青少年的神经精神疾病。患有 ADHD 的个体表现出异质的问题，如注意力困难、行为多动和冲动。最近的研究表明，复杂的遗传因素在注意力缺陷多动障碍中起作用。具有明确遗传特征的动物模型对于研究 ADHD 的分子、生物学和脑回路机制至关重要。由于其遗传起源管理良好，并且神经元回路功能的明确建立相对简单，因此，小鼠模型有助于了解 ADHD 所涉及的机制。因此，在这篇综述中，我们强调了可用于研究 ADHD 的重要遗传动物模型。
