Jen K-L Catherine, Buison Anne, Pellizzon Michael, Ordiz Frank, Santa Ana Lardo, Brown Jordana
Department of Nutrition and Food Science, Wayne State University, Detroit, Michigan 48202, USA.
Exp Biol Med (Maywood). 2003 Jul;228(7):843-9. doi: 10.1177/15353702-0322807-10.
High-fat diets made with different fats may have distinct effects on body weight regulation and metabolism. In the present study, the metabolic effects of high-fat (HF) diets made with fish oil, palm oil, and soybean oil were compared with a low-fat diet in female Wistar rats that were either exercised (EX, swimming) or that remained sedentary as controls. Each adult rat was exposed to the same diet that their dams consumed during pregnancy and lactation. When they were 9 weeks old, rats began an EX regimen that lasted for 6 weeks. Twenty-four hours after the last EX bout, rats were sacrificed in a fasted state. It was observed that HF feeding of soybean oil induced more body weight and fat gain, as well as insulin resistance, as indicated by insulin/glucose ratios, than other oils. Female rats fed a HF diet made with fish oil had body weight and insulin sensitivity not different from that observed in low fat fed control rats. For rats fed HF diets made with soybean oil or palm oil, EX also exerted beneficial effects by reducing body fat %, blood insulin, triglyceride and leptin levels, as well as improving insulin sensitivity.
用不同脂肪制成的高脂饮食可能对体重调节和新陈代谢有不同影响。在本研究中，将用鱼油、棕榈油和大豆油制成的高脂（HF）饮食与低脂饮食对雌性Wistar大鼠的代谢影响进行了比较，这些大鼠要么进行运动（EX，游泳），要么作为对照保持久坐。每只成年大鼠都食用与其母鼠在怀孕和哺乳期间相同的饮食。当它们9周大时，大鼠开始持续6周的运动方案。在最后一次运动 bout 后24小时，大鼠在禁食状态下被处死。观察到，与其他油相比，用大豆油进行高脂喂养诱导了更多的体重和脂肪增加，以及胰岛素抵抗，如胰岛素/葡萄糖比值所示。用鱼油制成的高脂饮食喂养的雌性大鼠的体重和胰岛素敏感性与低脂喂养的对照大鼠中观察到的无差异。对于用大豆油或棕榈油制成的高脂饮食喂养的大鼠，运动还通过降低体脂百分比、血液胰岛素、甘油三酯和瘦素水平以及提高胰岛素敏感性发挥了有益作用。
