Fernandez-Guasti A, Picazo O
Departamento de Farmacología, Centro de Investigación y Estudios Avanzados, México D.F.
Psychoneuroendocrinology. 1992 Nov;17(6):681-9. doi: 10.1016/0306-4530(92)90027-5.
This study demonstrates changes in cumulative burying behavior during various phases of the rat estrous cycle. Low levels of burying behavior were observed during late proestrus. Similar burying behavior levels among females tested in early proestrus, metestrus or diestrus and ovariectomized females were found. In ovariectomized females, treatment with estrogen (E) produced a slight, non-significant reduction in burying behavior. In contrast, progesterone (P) treatment resulted in a dose-dependent, statistically significant decrease in time spent burying. The combined treatment of E and P produced no effect. These data are discussed from the standpoint of the putative anxiolytic effect of P.
本研究证明了大鼠发情周期各阶段累积埋土行为的变化。在发情前期后期观察到埋土行为水平较低。发现在发情前期早期、发情后期或间情期接受测试的雌性以及卵巢切除的雌性中，埋土行为水平相似。在卵巢切除的雌性中，用雌激素（E）治疗使埋土行为略有减少，但无统计学意义。相比之下，孕酮（P）治疗导致埋土时间呈剂量依赖性、具有统计学意义的减少。E和P联合治疗没有效果。从P假定的抗焦虑作用的角度对这些数据进行了讨论。
