Pavlovska Oksana, Savelyeva Olga, Pavlovska Kateryna
Department of Obstetrics and Gynaecology, Odesa National Medical University, Odesa, Ukraine.
Department of Internal Medicine No1, Odesa National Medical University, Odesa, Ukraine.
Prz Menopauzalny. 2024 Sep;23(3):145-151. doi: 10.5114/pm.2024.143481. Epub 2024 Oct 14.
The thyroid gland has a significant impact on the morphofunctional state of the organs of the female reproductive system, the regulation of the ovarian-menstrual cycle, as well as the age-related decline of the generative and endocrine function of the ovaries.
The study involved 102 women aged 49-62 years, who were divided into 2 groups. Group I included 54 patients who suffered from manifestations of the menopausal syndrome, and the control group comprised 48 patients whose menopausal period proceeded physiologically. All patients underwent clinical, laboratory, and instrumental examinations in accordance with the requirements of modern protocols.
A thyroid dysfunction has a significant impact on the course of menopause. In women who suffered from manifestations of pathological menopause, the thyroid dysfunction was detected in 64.81% of patients, with the most frequently diagnosed being hypothyroid state (61.11%). Among thyroid diseases, chronic autoimmune thyroiditis prevailed (37.04%), and diffuse focal and focal changes were observed in 24.07% of cases. In patients with uncomplicated menopause, thyroid pathology was diagnosed 3.9 times less frequently. No autoimmune thyropathies were identified among the patients in the control group; focal pathology (category TI-RADS1 and TI-RADS2) was detected in 14.58% of cases.
Thyroid dysfunction accompanied by hypothyroidism can be considered as a risk-stratification factor for the development of pathological menopause.
甲状腺对女性生殖系统器官的形态功能状态、卵巢-月经周期的调节以及卵巢生殖和内分泌功能的年龄相关性衰退具有重大影响。
该研究纳入了102名年龄在49至62岁之间的女性，她们被分为两组。第一组包括54名患有绝经综合征表现的患者，对照组由48名绝经过程正常的患者组成。所有患者均按照现代方案的要求进行了临床、实验室和仪器检查。
甲状腺功能障碍对绝经进程有重大影响。在患有病理性绝经表现的女性中，64.81%的患者检测出甲状腺功能障碍，最常诊断的是甲状腺功能减退状态（61.11%）。在甲状腺疾病中，慢性自身免疫性甲状腺炎最为常见（37.04%），24.07%的病例观察到弥漫性局灶性和局灶性改变。在绝经未出现并发症的患者中，甲状腺病变的诊断频率低3.9倍。对照组患者中未发现自身免疫性甲状腺疾病；14.58%的病例检测出局灶性病变（TI-RADS1和TI-RADS2类别）。
伴有甲状腺功能减退的甲状腺功能障碍可被视为病理性绝经发生的风险分层因素。
