Müller Hannes M, Widschwendter Martin
Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria.
Expert Rev Mol Diagn. 2003 Jul;3(4):443-58. doi: 10.1586/14737159.3.4.443.
Early detection appears to be one of the most important approaches to reducing mortality caused by neoplasia. Changes in DNA methylation have been recognized as one of the most common molecular alterations in human tumors. Due to the ubiquity of DNA methylation changes and the possibility to detect methylated DNA in several body fluids, this specifically altered DNA may serve as a potential new screening marker for neoplastic disease.
早期检测似乎是降低肿瘤所致死亡率的最重要方法之一。DNA甲基化变化已被公认为人类肿瘤中最常见的分子改变之一。由于DNA甲基化变化普遍存在，且有可能在多种体液中检测到甲基化DNA，这种特异性改变的DNA可能成为肿瘤疾病潜在的新型筛查标志物。
