Ulger Harun, Erdogan Nuri, Kumanlioglu Sadan, Unur Erdogan
Departments of Anatomy and Radiology, Gevher Nesibe Hospital, Erciyes University, 38039 Kayseri, Turkey.
Skin Res Technol. 2003 Aug;9(3):284-9. doi: 10.1034/j.1600-0846.2003.00027.x.
BACKGROUND/PURPOSE: The localized or generalized skin thickness detected on mammography may reflect an underlying pathology of breast or a systemic disease involving the skin. The aim of this report is to describe the range of normal breast skin thickness in women using a film-screen mammographic technique.
Measurement of the mammographic skin thickness over different parts of the breast was performed in 144 women who had normal findings in a combined mammographic and ultrasonographic examination. Patients were grouped as premenopause, postmenopause and surgical menopause who were under continuous oestrogen treatment. The skin thickness in four regions (superior, inferior, medial, lateral) of both breasts was compared, and their relations with age, breast size, menopausal and hormonal status were investigated. The interobserver reliability was tested in a small subgroup of patients.
Interobserver agreement was good for all measurements. The range of normal breast skin thickness was between 0.50 and 3.10 mm. There were no differences in skin thickness between the corresponding regions of the breasts, with significant differences between the regions in the same breast. While breast size increased with age, skin thickness decreased in all regions.
The breast size, age, regional variations and hormonal status of the patients should be considered when defining the normal range of skin thickness in mammographic examinations. We assume that upper limit of mammographic skin thickness should be set as 3.0 mm, regardless of the focal spot size and film-focus distance.
背景/目的：乳腺钼靶检查中检测到的局部或全身性皮肤厚度可能反映潜在的乳腺病理状况或累及皮肤的全身性疾病。本报告的目的是使用屏-片乳腺钼靶技术描述女性正常乳腺皮肤厚度的范围。
对144名在乳腺钼靶和超声联合检查中结果正常的女性进行了乳腺不同部位钼靶皮肤厚度的测量。患者被分为绝经前、绝经后和接受持续雌激素治疗的手术绝经组。比较了双侧乳房四个区域（上、下、内、外）的皮肤厚度，并研究了它们与年龄、乳房大小、绝经和激素状态的关系。在一小部分患者亚组中测试了观察者间的可靠性。
所有测量的观察者间一致性良好。正常乳腺皮肤厚度范围在0.50至3.10毫米之间。双侧乳房相应区域的皮肤厚度无差异，同一乳房不同区域之间存在显著差异。虽然乳房大小随年龄增加，但所有区域的皮肤厚度均下降。
在定义钼靶检查中皮肤厚度的正常范围时，应考虑患者的乳房大小、年龄、区域差异和激素状态。我们认为，无论焦点尺寸和胶片-焦点距离如何，钼靶皮肤厚度的上限应设定为3.0毫米。
