Nakano Tadao, Murata Koichi, Ikeda Yatsukaho, Hasegawa Hideo
Department of Infectious Diseases, Oita Medical University, Hasama, Oita 879-5593, Japan.
J Parasitol. 2003 Jun;89(3):439-43. doi: 10.1645/0022-3395(2003)089[0439:GOEVIA]2.0.CO;2.
The growth of Enterobius vermicularis in a chimpanzee was investigated by observing worms discharged in feces after administration of pyrantel pamoate. Just after the final molting, immature adult male pinworms developed to a fully mature stage in 2 wk, after passing through a stage corresponding to the so-called Enterobius gregorii, which was surmised to be a younger adult form of E. vermicularis. The frequency distribution of body length forms 2 peaks in both male and female pinworms, with a depression in the transitional forms from the immature to the fully mature stage. This depression seems to be the result of more rapid growth or lower susceptibility to the drug in this transitional stage. Pyrantel pamoate effectively eradicated mature males, but gravid females were continuously observed in the feces after treatment. The complete eradication of pinworm infection by pyrantel pamoate could be achieved by repeated treatment at intervals shorter than 2 wk. This treatment would eradicate male worms first, resulting in females producing only unfertilized eggs, from which only males might hatch.
通过观察服用双羟萘酸噻嘧啶后粪便中排出的蠕虫，对黑猩猩体内蠕形住肠线虫的生长情况进行了研究。刚完成最后一次蜕皮后，未成熟的成年雄性蛲虫在2周内发育到完全成熟阶段，在此之前经历了一个相当于所谓的格雷戈里氏蛲虫的阶段，推测这是蠕形住肠线虫较年轻的成年形态。雄雌蛲虫体长的频率分布均形成两个峰值，在从未成熟到完全成熟阶段的过渡形态处有一个低谷。这种低谷似乎是由于在这个过渡阶段生长更快或对药物的敏感性较低所致。双羟萘酸噻嘧啶有效地根除了成熟雄性，但治疗后粪便中仍持续观察到妊娠雌虫。通过间隔短于2周的重复治疗，可以实现双羟萘酸噻嘧啶对蛲虫感染的完全根除。这种治疗首先会根除雄虫，导致雌虫只产出未受精卵，而这些卵可能只能孵化出雄虫。
