Nakano Tadao, Fukui Daisuke, Ikeda Yatsukaho, Hasegawa Hideo
Department of Infectious Diseases, Faculty of Medicine, Oita University, Hasama, Oita 879-5593, Japan.
J Parasitol. 2005 Jun;91(3):679-82. doi: 10.1645/GE-412R.
Effects of repeated treatment with pyrantel pamoate on Enterobius vermicularis infection in chimpanzees were assessed by observing worms discharged in the feces after administration of anthelmintic treatment. Three of 9 chimpanzees reared in a zoological garden in Japan were subjected to fecal worm count and morphometric observation, and all were given oral pyrantel pamoate 6 times at 10-day intervals simultaneously. Following the first and second treatments, more than 30,000 pinworms were discharged from 1 chimpanzee. The number of discharged worms abruptly decreased after the third treatment, and only a few worms were recovered after the fifth treatment, indicating that repeated treatment at short intervals was very effective. Complete eradication was not achieved, however, presumably because of reinfection. The female proportion among discharged worms tended to increase as the treatment was repeated.
通过观察驱虫治疗后粪便中排出的蠕虫，评估了用吡喹酮重复治疗对黑猩猩蛲虫感染的影响。在日本一家动物园饲养的9只黑猩猩中，有3只接受了粪便蠕虫计数和形态测量观察，并且所有黑猩猩都同时每隔10天口服6次吡喹酮。在第一次和第二次治疗后，1只黑猩猩排出了超过30000条蛲虫。第三次治疗后排出的蠕虫数量急剧下降，第五次治疗后仅回收了几只蠕虫，这表明短时间间隔重复治疗非常有效。然而，由于再次感染，并未实现完全根除。随着治疗的重复，排出蠕虫中的雌性比例趋于增加。
