Verkaaik A P, Erdmann W, van Dijk G, Westerkamp B
Dept. of Anesthesiology, Erasmus University Rotterdam, The Netherlands.
Adv Exp Med Biol. 1992;316:195-202. doi: 10.1007/978-1-4615-3404-4_23.
A totally closed feed back controlled anesthesia- and ventilation circuit has been developed feasible to be applied for artificial ventilation with tidal volumes as low as 5 ml at a rate of up to 60/min and for spontaneous ventilation with on-line measurement of physiological lung parameters (pressure, volume, flow). Oxygen inflow is regulated via actual-set value comparison, oxygen inflow is measured and recorded on-line (= oxygen uptake by the connected subject). On-line oxygen uptake (consumption) measurement furnishes a valuable, so far not available parameter to monitor changes in the oxygen transport chain to the tissue and to register physiological oxygen consumption values and derangement of metabolism. First results show that total body oxygen consumption of man in rest is lower than so far expected in the high weight and body surface area groups and that oxygen consumption is decreasing with length and age. Metabolic derangements such as in developing hyperthermia crisis are noticed in a very early stage when therapy is still possible before severe damage has occurred.
已开发出一种完全封闭的反馈控制麻醉和通气回路，可用于潮气量低至5毫升、频率高达60次/分钟的人工通气，以及用于在线测量生理肺参数（压力、容积、流量）的自主通气。通过实际值与设定值比较来调节氧气流入量，在线测量并记录氧气流入量（即连接对象的氧气摄取量）。在线氧气摄取（消耗）测量提供了一个有价值的、迄今为止尚未有的参数，用于监测向组织的氧转运链中的变化，并记录生理氧消耗值和代谢紊乱情况。初步结果表明，在高体重和体表面积组中，静息状态下人体的全身氧消耗低于迄今为止的预期，并且氧消耗随着身长和年龄的增长而降低。在仍有可能进行治疗、尚未发生严重损害的非常早期阶段，就能察觉到诸如高热危象发展过程中的代谢紊乱情况。
