Kamler M, Lehr H A, Saetzler R K, Galla T J, Messmer K
Department of Experimental Surgery, University of Heidelberg, FRG.
Adv Exp Med Biol. 1992;316:419-24. doi: 10.1007/978-1-4615-3404-4_47.
The influence of vasoactive medication on tissue oxygenation and wound healing was investigated in the ear model of the hairless mouse. Ischemia was induced to the ears by ligating 2 of the 3 main vessel bundels and verified by measurements of tcpO2. Reduced tissue oxygenation was followed by a prolongation of the time required for complete healing of standardized wounds. Treatment with the vasoactive drug Buflomedil (3 mg/kg/day iv.) resulted in enhanced recovery of the tissue from reduced oxygenation and likewise reversed the adverse effects of ischemia on wound healing. These results warrant the use of the drug in patients suffering from delayed wound healing due to peripheral arterial disease.
在无毛小鼠耳部模型中研究了血管活性药物对组织氧合和伤口愈合的影响。通过结扎三条主要血管束中的两条来诱导耳部缺血，并通过测量经皮氧分压（tcpO2）进行验证。组织氧合降低后，标准化伤口完全愈合所需的时间延长。使用血管活性药物丁咯地尔（3毫克/千克/天，静脉注射）治疗可增强组织从低氧状态的恢复，同样也可逆转缺血对伤口愈合的不利影响。这些结果证明该药物可用于因外周动脉疾病导致伤口愈合延迟的患者。
