Quirinia A, Gottrup F, Viidik A
Department of Connective Tissue Biology, University of Aarhus, Denmark.
Scand J Plast Reconstr Surg Hand Surg. 1996 Jun;30(2):81-7. doi: 10.3109/02844319609056388.
The effect of buflomedil and isoxsuprine on the healing of ischaemic wounds was investigated using an ischaemic flap model previously evaluated on rats. The drugs were given twice daily intraperitoneally for a total of nine days starting on the day before operation. The wounds were tested biomechanically after 10 and 20 days of healing, respectively, and the length of surface necrosis on the flaps was measured after 10 days. The study showed no differences in any of the biomechanical (functional) parameters of the ischaemic wounds compared with the control groups, either after 10 or 20 days of healing. There were no differences in the length of surface necrosis on the flaps. Neither of these drugs has so far convincingly proved to be effective in the treatment of ischaemic wounds or flaps.
使用先前在大鼠身上评估过的缺血皮瓣模型，研究了丁咯地尔和异克舒令对缺血性伤口愈合的影响。从手术前一天开始，每天两次腹腔注射药物，共九天。分别在伤口愈合10天和20天后进行生物力学测试，并在10天后测量皮瓣表面坏死的长度。研究表明，与对照组相比，缺血性伤口在愈合10天或20天后的任何生物力学（功能）参数均无差异。皮瓣表面坏死的长度也没有差异。迄今为止，这两种药物均未令人信服地证明对治疗缺血性伤口或皮瓣有效。
