Baldi James C, McFarlane Kendra, Oxenham Helen C, Whalley Gillian A, Walsh Helen J, Doughty Robert N
Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand.
J Appl Physiol (1985). 2003 Dec;95(6):2570-5. doi: 10.1152/japplphysiol.00441.2003. Epub 2003 Jul 25.
Aging is associated with impaired early diastolic filling; however, the effect of endurance training on resting diastolic function in older subjects is unclear. Heart rate and ventricular loading conditions affect mitral inflow velocities measured by Doppler echocardiography; therefore, tissue Doppler imaging of mitral annular velocity, which is relatively preload independent, was combined with mitral inflow velocity and maximal oxygen consumption (V(o2 max)) in young (20-35 yr) and older (60-80 yr) trained and untrained men to determine whether endurance training is associated with an attenuation of age-associated changes in diastolic filling. As expected, V(o2 max) was higher in trained men (P < 0.01) and lower in older men (P < 0.01). Peak early mitral inflow velocity (E) and early-to-late mitral inflow velocity ratios were lower in older vs. young men (P < 0.01); however, there was no training effect (P > 0.05). Peak early mitral annular velocity (E') was higher and peak late mitral annular velocity (A') was lower in young vs. older men (P < 0.01). A significant interaction effect was found for A', E'/A', and peak systolic mitral annular velocity (S'). Training was associated with lower A' in young and higher A' in older men. S' was greater in trained vs. untrained older men (P < 0.05), but it was similar in trained and untrained young men. These findings suggest that early diastolic filling is not affected by training in older men, and the effect of training on A' and S' is different in young and older men.
衰老与舒张早期充盈受损有关；然而，耐力训练对老年受试者静息舒张功能的影响尚不清楚。心率和心室负荷情况会影响通过多普勒超声心动图测量的二尖瓣流入速度；因此，将相对独立于前负荷的二尖瓣环速度组织多普勒成像与二尖瓣流入速度和最大耗氧量（V̇o₂ max）相结合，对年轻（20 - 35岁）和老年（60 - 80岁）的受过训练和未受过训练的男性进行研究，以确定耐力训练是否与舒张期充盈中与年龄相关变化的减弱有关。正如预期的那样，受过训练的男性V̇o₂ max较高（P < 0.01），而老年男性较低（P < 0.01）。与年轻男性相比，老年男性的二尖瓣早期流入峰值速度（E）和二尖瓣早期与晚期流入速度比值较低（P < 0.01）；然而，没有训练效果（P > 0.05）。与老年男性相比，年轻男性的二尖瓣环早期峰值速度（E'）较高，二尖瓣环晚期峰值速度（A'）较低（P < 0.01）。发现A'、E'/A'和二尖瓣环收缩期峰值速度（S'）存在显著的交互作用。训练与年轻男性较低的A'和老年男性较高的A'有关。受过训练的老年男性的S'大于未受过训练的老年男性（P < 0.05），但在受过训练和未受过训练的年轻男性中相似。这些发现表明，早期舒张期充盈不受老年男性训练的影响，并且训练对A'和S'的影响在年轻和老年男性中有所不同。
