硅水凝胶隐形眼镜佩戴期间闭眼对晶状体后泪膜厚度的影响。

The effect of eye closure on the post-lens tear film thickness during silicone hydrogel contact lens wear.

作者信息

Nichols Jason J, King-Smith P Ewen

机构信息

The Ohio State University College of Optometry, 320 West 10th Avenue, PO Box 182342, Columbus, OH 43218-2342, USA.

出版信息

Cornea. 2003 Aug;22(6):539-44. doi: 10.1097/00003226-200308000-00010.

DOI:10.1097/00003226-200308000-00010

PMID:12883347

Abstract

PURPOSE

The purpose of this study was to investigate the effect of eye closure on the thickness on the post-lens tear film (POLTF) during silicone hydrogel contact lens wear.

METHODS

Ten subjects (mean age, 30.2 +/- 8.6 years; seven males) wore balafilcon A silicone hydrogel contact lenses in both eyes during the experimental procedure (power = -2.00 D, base curve = 8.6 mm). Previously described interference techniques, based on oscillations in reflectance spectra, were used to measure the post-lens tear film. Reflectance spectra (562-1030 nm) from the front of the eye wearing a contact lens were measured at normal incidence where the thickness of the POLTF was derived from the "frequency" of the oscillations. Six baseline measures of POLTF thickness were taken, followed by eye closure in the supine position for 30 minutes. Post-lens tear film thickness measures were taken after 5 and 15 minutes of eye closure. After 30 minutes of eye closure, 1 measure of POLTF was taken every minute for an additional 15 minutes.

RESULTS

The average baseline POLTF thickness was 2.00 +/- 0.30 microm (median, 2.00) for the 10 subjects. The average POLTF thickness decreased to 1.58 +/- 0.33 and 1.20 +/- 0.23 microm after 5 and 15 minutes of eye closure, respectively (repeated measures ANOVA, F = 42.18, P < 0.0001). Only 5 of 60 POLTF thickness estimates were obtained for the first 6 minutes following completion of 30 minutes of eye closure, indicating that the POLTF may be too thin (i.e., <1 microm) to measure using this method. However, there was a significant increase in POLTF thickness for 15 minutes after prolonged eye closure (mixed modeling regression, thickness = 0.85 + 0.07 x time after eye opening; P < 0.0001).

CONCLUSIONS

The POLTF thickness is rapidly reduced by eye closure during contact lens wear. After 30 minutes of eye closure, the POLTF thickness may be reduced to values less than 1 microm for the first several minutes after opening the eyes.

摘要

目的

本研究旨在调查在佩戴硅水凝胶隐形眼镜期间闭眼对晶状体后泪膜（POLTF）厚度的影响。

方法

10名受试者（平均年龄30.2±8.6岁；7名男性）在实验过程中双眼佩戴balafilcon A硅水凝胶隐形眼镜（屈光度=-2.00 D，基弧=8.6 mm）。基于反射光谱振荡的先前描述的干涉技术用于测量晶状体后泪膜。在垂直入射时测量佩戴隐形眼镜的眼睛前部的反射光谱（562 - 1030 nm），其中POLTF的厚度由振荡的“频率”得出。对POLTF厚度进行6次基线测量，然后受试者仰卧位闭眼30分钟。闭眼5分钟和15分钟后测量晶状体后泪膜厚度。闭眼30分钟后，在接下来的15分钟内每分钟测量1次POLTF。

结果

10名受试者的平均基线POLTF厚度为2.00±0.30微米（中位数为2.00）。闭眼5分钟和15分钟后，POLTF平均厚度分别降至1.58±0.33微米和1.2±0.23微米（重复测量方差分析，F = 42.18，P < 0.0001）。在闭眼30分钟结束后的前6分钟内，仅获得了60次POLTF厚度估计中的5次，这表明POLTF可能太薄（即<1微米）以至于无法使用此方法测量。然而，长时间闭眼后15分钟内POLTF厚度有显著增加（混合模型回归，厚度 = 0.85 + 0.07×睁眼后的时间；P < 0.0001）。