Nichols Jason J, Mitchell G Lynn, King-Smith P Ewen
College of Optometry, The Ohio State University, Columbus, OH 43218-2342, USA.
Cornea. 2005 Oct;24(7):825-32. doi: 10.1097/01.ico.0000157904.52305.29.
To determine the impact of compositional differences in contact lens care solutions on the thickness of the tear film during contact lens wear.
A randomized, crossover, investigator-masked clinical trial was conducted to compare AMO's Complete MoisturePlus to Alcon's Opti-Free Express in 31 subjects. The primary outcome of this study was a comparison of prelens tear film (PLTF) and postlens tear film (PoLTF) thickness values obtained during the first 2 hours of etafilcon A hydrogel lens wear. Each solution was used by each participant for a period of 7 days, separated by a washout period of 1 day. Alternative outcomes studied included prelens tear film thinning rates, solution preference, and dry eye-related symptom scores. Tear film thickness measurements were made using a noninvasive wavelength-dependent interferometric system.
The average overall PLTF thickness over the 120-minute time period after using Complete MoisturePlus was 3.02 +/- 1.07 microm, whereas the average overall PLTF thickness in this same time interval after using Opti-Free Express was 2.72 +/- 0.86 (P = 0.003). For both solutions, the PLTF could be fitted by the sum of an exponential decay plus a constant. The PLTF decay amplitudes did not statistically differ when the solutions were compared (P = 0.11). There was no difference in overall PoLTF thicknesses when the average values after using each solution were compared (P = 0.57), although there was a difference immediately after the lens was applied to the eye (Complete MoisturePlus average = 4.10 versus Opti-Free Express average = 3.48, P = 0.02). The PoLTF also demonstrated an exponential decay for both solutions. The PoLTF decay amplitudes did not statistically differ (P = 0.14). Twenty subjects (64.5%) preferred Complete MoisturePlus to Opti-Free Express (35.5%) (P = 0.11), and nearly every subject (90.3%) suggested "comfort" as their reason for preference.
Complete MoisturePlus is associated with a thicker PLTF when compared with Opti-Free Express in contact lens wearers without dry eye symptoms, especially during the first 5 minutes following lens insertion.
确定隐形眼镜护理液成分差异对隐形眼镜佩戴过程中泪膜厚度的影响。
进行了一项随机、交叉、研究者设盲的临床试验，在31名受试者中比较AMO的Complete MoisturePlus和爱尔康的Opti-Free Express。本研究的主要结果是比较在佩戴依他氟康水凝胶镜片的前2小时内获得的镜片前泪膜（PLTF）和镜片后泪膜（PoLTF）厚度值。每位参与者使用每种护理液7天，中间间隔1天的洗脱期。研究的其他结果包括镜片前泪膜变薄率、护理液偏好和干眼相关症状评分。使用非侵入性波长相关干涉测量系统测量泪膜厚度。
使用Complete MoisturePlus后120分钟内的平均总PLTF厚度为3.02±1.07微米，而使用Opti-Free Express后同一时间间隔内的平均总PLTF厚度为2.72±0.86（P = 0.003）。对于两种护理液，PLTF都可以用指数衰减加常数之和来拟合。比较两种护理液时，PLTF衰减幅度在统计学上没有差异（P = 0.11）。比较使用每种护理液后的平均值时，PoLTF总厚度没有差异（P = 0.57），尽管在镜片戴到眼睛上后立即有差异（Complete MoisturePlus平均值 = 4.10，而Opti-Free Express平均值 = 3.48，P = 0.02）。两种护理液的PoLTF也都表现出指数衰减。PoLTF衰减幅度在统计学上没有差异（P = 0.14）。20名受试者（64.5%）比Opti-Free Express（35.5%）更喜欢Complete MoisturePlus（P = 0.11），几乎每个受试者（90.3%）都表示“舒适度”是他们偏好的原因。
在没有干眼症状的隐形眼镜佩戴者中（尤其是在镜片插入后的前5分钟内），与Opti-Free Express相比，Complete MoisturePlus与更厚的PLTF相关。
