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药物修饰隐形眼镜 - 活性物质的特性、释放动力学和稳定性，特别强调环孢素 A：综述。

Drug-Modified Contact Lenses-Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review.

机构信息

Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8, 61-614 Poznan, Poland.

Department of Ophthalmology, Military Institute of Medicine, ul. Szaserów 128, 04-141 Warsaw, Poland.

出版信息

Molecules. 2024 Jun 1;29(11):2609. doi: 10.3390/molecules29112609.

DOI:10.3390/molecules29112609
PMID:38893485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11173495/
Abstract

The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses. It discusses the types of drugs embedded into contact lenses, the various polymeric materials used in their production, methods for assessing the mechanical properties of polymers, and techniques for studying drug release kinetics. The article also explores strategies for investigating the stability of active substances released from contact lenses. It specifically emphasizes the production of soft contact lenses modified with Cyclosporine A (CyA) for the topical treatment of specific ocular conditions. The review pays attention to methods for monitoring the stability of Cyclosporine A within the discussed DDS, as well as investigating the influence of polymer matrix type on the stability and release of CyA.

摘要

以下综述重点介绍了使用聚合物材料制造和参数化眼部药物传递系统 (DDS) 以制造软性隐形眼镜。讨论了嵌入隐形眼镜中的药物类型、用于生产它们的各种聚合物材料、评估聚合物机械性能的方法以及研究药物释放动力学的技术。文章还探讨了研究从隐形眼镜中释放的活性物质稳定性的策略。它特别强调了用环孢素 A (CyA) 生产软性隐形眼镜，以局部治疗特定的眼部疾病。该综述关注监测讨论的 DDS 中环孢素 A 稳定性的方法，以及研究聚合物基质类型对 CyA 稳定性和释放的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/9a9665756f31/molecules-29-02609-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/954fa8b0fbc0/molecules-29-02609-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/1a984497faa3/molecules-29-02609-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/9602c133626d/molecules-29-02609-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/51410f537ee1/molecules-29-02609-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/453e76e65acd/molecules-29-02609-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/9a9665756f31/molecules-29-02609-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/954fa8b0fbc0/molecules-29-02609-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/5373458dcd9a/molecules-29-02609-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/1a984497faa3/molecules-29-02609-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/9602c133626d/molecules-29-02609-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/512c/11173495/9a9665756f31/molecules-29-02609-g007.jpg

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