Gai Ming-ying, Zhang Jian-ping, Li Yang, Han Hong-jing, Yang Jian-qiu, Wang Shan-mi, Su Qi-feng, Wu Lian-fang
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhonghua Fu Chan Ke Za Zhi. 2003 Apr;38(4):210-2.
To explore the efficacy and safety of continuously released prostaglandin E(2) (PGE(2)) suppository-propess used for induction of term pregnancy.
A multicenter, prospective, case control clinical study was carried out, propess was used in 100 cases as study group, the suppository without PGE(2) was used in 49 cases as control group. The cervical maturity (by Bishop scoring), the time to labor starting, membrane rupture and delivery, the application of oxytocin, ceserean section rate, fetal and neonatal condition were compared between 2 groups after inserting of the suppository. At the same time, side effects caused by propess were investigated.
Bishop score was increased >or= 2 points in 93% cases, >or= 3 points in 87% cases in study group, whereas only 4% cases whose Bishop score increased >or= 2 points in control group. The time to labor starting, membrane rupture, and delivery was shortened obviously in study group than that in control group after inserting suppository. The application of oxytocin was much less in study group, cesarean section rate was reduced in study group (32% vs 61%). There was no significant difference between 2 groups in fetal and neonatal conditions. The overstimulation of uterine contraction and mild gastrointestinal tract reaction occurred in 3 cases and 2 cases respectively in study groups.
Propess can be used for induction of term pregnancy effectively and safely.
探讨持续释放前列腺素E₂（PGE₂）栓剂—普贝生用于足月妊娠引产的有效性和安全性。
进行一项多中心、前瞻性、病例对照临床研究，100例使用普贝生作为研究组，49例使用不含PGE₂的栓剂作为对照组。比较两组在放置栓剂后宫颈成熟度（采用Bishop评分）、开始宫缩时间、胎膜破裂及分娩时间、缩宫素应用情况、剖宫产率、胎儿及新生儿情况。同时，调查普贝生引起的副作用。
研究组93%的病例Bishop评分增加≥2分，87%的病例增加≥3分，而对照组仅有4%的病例Bishop评分增加≥2分。放置栓剂后，研究组开始宫缩、胎膜破裂及分娩时间明显短于对照组。研究组缩宫素应用少得多，研究组剖宫产率降低（32%对61%）。两组胎儿及新生儿情况无显著差异。研究组分别有3例和2例发生子宫收缩过强和轻度胃肠道反应。
普贝生可有效、安全地用于足月妊娠引产。
