Chernysheva G A, Plotnikov M B, Bisenieks E A, Makarova N V, Ul'driks Ia R, Dubur G Ia
Eksp Klin Farmakol. 1993 Mar-Apr;56(2):19-21.
Intravenous cerebrocrast, 1 g/kg/min, and nicardipine, 0.5 g/kg/min, given to cats during 60 min one day after cerebral hemorrhage were found to produce an improvement of cerebral blood supply and oxygen consumption along with a moderate fall of blood pressure. The favourable effect of cerebrocrast on brain oxygen and carbohydrate metabolism was mediated by increased brain blood supply. As compared to cerebrocrast, nicardipine induced a more prolonged antihypertensive response and more pronounced effects on cerebral tissue metabolism, by substantially decreasing brain lactate production.
