Gonzalez M A, Biswas S, Clifton L, Corrie P G
Oncology Centre (Box 193), Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Br J Cancer. 2003 Aug 4;89(3):455-6. doi: 10.1038/sj.bjc.6601167.
A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin. Overall objective response rate was 53% and tolerability was excellent.
迄今为止,尚未确立针对转移性神经内分泌肿瘤(NETs)的标准化、有效的全身治疗方法。我们回顾了15例无法手术的转移性NET患者采用氟尿嘧啶持续静脉滴注、亚叶酸钙和链脲佐菌素联合化疗方案进行系统治疗的情况。总体客观缓解率为53%,耐受性良好。