Merzhanova G Kh, Dolbakian E E, Khokhlova V N
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 2003 May-Jun;53(3):290-8.
Six cats were subjected to the procedure of appetitive instrumental conditioning (with light as a conditioned stimuls) by the method of the "active choice" of reinforcement quality. Short-delay conditioned bar-press responses were rewarded with bread-meat mixture, and the delayed responses were reinforced by meat. The animals differed in behavior strategy: four animals preferred the bar-pressing with a long delay (the so-called "self-control" group), and two cats preferred the bar-pressing with a short delay (the so-called "impulsive" group). Multiunit activity in the frontal cortex and hippocampus (CA3) was recorded via chronically implanted nichrome wire semimicroelectrodes. An interaction between the neighboring neurons in the frontal cortex and hippocampus (within local neural networks) and between the neurons of the frontal cortex and hippocampus (distributed neural networks in frontal-hippocampal and hippocampal-frontal directions) was evaluated by means of statistical crosscorrelation analysis of spike trains. Crosscorrelations between neuronal spike trains in the delay range of 0-100 ms were explored. It was shown that the number of crosscorrelations between the neuronal discharges both in the local and distributed networks was significantly higher in the "self-control" cats. It was suggested that the local and distributed neural networks of the frontal cortex and hippocampus are involved in the system of brain structures which determine the behavioral strategy of animals in the "self-control" group.
通过强化质量的“主动选择”方法，对六只猫进行了食欲性工具性条件反射实验（以光作为条件刺激）。短延迟条件下的压杆反应会得到面包 - 肉混合物作为奖励，而延迟反应则用肉进行强化。这些动物在行为策略上有所不同：四只动物更喜欢长时间延迟的压杆行为（即所谓的“自我控制”组），两只猫更喜欢短时间延迟的压杆行为（即所谓的“冲动”组）。通过长期植入的镍铬合金丝半微电极记录额叶皮质和海马体（CA3）中的多单位活动。通过对尖峰序列进行统计互相关分析，评估额叶皮质和海马体中相邻神经元之间（在局部神经网络内）以及额叶皮质和海马体神经元之间（在额叶 - 海马体和海马体 - 额叶方向的分布式神经网络中）的相互作用。探索了0 - 100毫秒延迟范围内神经元尖峰序列之间的互相关性。结果表明，“自我控制”组猫的局部和分布式网络中神经元放电之间的互相关数量明显更高。研究表明，额叶皮质和海马体的局部和分布式神经网络参与了决定“自我控制”组动物行为策略的脑结构系统。
