Dolbakian E E, Merzhanova G Kh
Zh Vyssh Nerv Deiat Im I P Pavlova. 2006 Sep-Oct;56(5):653-63.
Appetitive instrumental conditioned reflexes on light (CS+) were formed in six cats by the method of "active choice" of quality of reinforcement; bread-meat mixture was given after short-delay conditioned bar-press responses, and the delayed responses were rewarded by meat. The animals differed in choice behavior strategy: "self-control", "ambivalent", "impulsive". The multiunit activity in the frontal cortex and hippocampus (CA3) was recorded. Cross-correlation analysis was used for estimation of correlation of activities in neuronal pairs in the frontal cortex and hippocampus (distributed frontal-hippocampal networks) and pairs within the same structure (frontal and hippocampal local neuronal networks). It was shown that the number of cross-correlations between the discharges of neurons both in the local and distributed networks was significantly higher in "self-control" cats. Under conditions of systemic administration of antagonists of muscarinic central cholinoreceptors (trihexyphenidyl and scopolamine), the bar-press conditioning impaired, the number of direct interneuronal connections decreased, and the number of externally synchronized correlations ("common input") significantly increased. The results suggest that the local and distributed neural networks of the frontal cortex and hippocampus are involved in the system of brain structures that determine the behavioral strategy of "self control".
通过强化质量“主动选择”的方法，在6只猫身上建立了对光（CS+）的食欲性工具性条件反射；在短延迟条件性压杆反应后给予面包 - 肉混合物，延迟反应则用肉作为奖励。这些动物在选择行为策略上存在差异：“自我控制型”、“矛盾型”、“冲动型”。记录了额叶皮质和海马体（CA3）中的多单位活动。采用互相关分析来估计额叶皮质和海马体中神经元对活动的相关性（分布式额叶 - 海马网络）以及同一结构内的神经元对活动相关性（额叶和海马体局部神经元网络）。结果表明，“自我控制型”猫的局部和分布式网络中神经元放电之间的互相关数量显著更高。在全身给予毒蕈碱型中枢胆碱能受体拮抗剂（苯海索和东莨菪碱）的情况下，压杆条件反射受损，直接的神经元间连接数量减少，而外部同步相关性（“共同输入”）的数量显著增加。结果表明，额叶皮质和海马体的局部和分布式神经网络参与了决定“自我控制”行为策略的脑结构系统。
