Sun Y Q, Lu S B, Wang J F
Department of Orthopaedics, PLA General Hospital, Beijing.
Chin Med J (Engl). 1992 Sep;105(9):742-8.
The effects of prostaglandin E2(PGE2) in vivo and in vitro on cementless fixation of porous coated implant were studied. The results revealed that high levels of PGE2 in the local tissue benefit bone ingrowth in the early stage of implantation. Co-Cr-Mo alloy itself hampers the growth of osteoblasts and decreases the local secretion of PGE2. In the early stage of arthroplasty, the use of PGE2 inhibitors should be forbidden, and proper loading stimulation is preferable. High level PGE2 of local tissue in the later stage indicates bone resorption.
研究了前列腺素E2（PGE2）在体内和体外对多孔涂层植入物非骨水泥固定的影响。结果显示，局部组织中高水平的PGE2有利于植入早期的骨长入。钴铬钼合金本身会阻碍成骨细胞的生长并减少PGE2的局部分泌。在关节成形术早期，应禁止使用PGE2抑制剂，适当的负荷刺激更为可取。后期局部组织中高水平的PGE2表明骨吸收。
