Department of Dermatology, School of Medicine, Kyunghee University, Seoul, Korea.
Int J Dermatol. 2010 Mar;49(3):317-23. doi: 10.1111/j.1365-4632.2009.04332.x.
Various repigmentation patterns such as perifollicular, marginal, diffuse, and mixed configuration can occur in vitiligo. The aim of this study was to clinically assess the types of repigmentation patterns obtained with narrow-band ultraviolet B (NBUVB) phototherapy or targeted phototherapy using a 308 nm excimer laser and to reveal whether the repigmentation patterns have any relationship to the location of lesions, patient's age, duration of lesions, or speed of improvement.
This study enrolled 51 patients who had effective responses as compared with baseline when treated with NBUVB alone and 52 patients who had effective responses as compared with baseline when treated with excimer laser alone. We evaluated the repigmentation patterns when the responses to treatments appeared.
The most frequent repigmentation pattern was the perifollicular type in both groups treated with NBUVB (42.2%) or excimer laser (51.3%), followed by marginal, diffuse, and combined, in that order. There was no significant difference in the repigmentation pattern according to the location of lesions, patient's age, or duration of lesions. The marginal pattern was predominant in both NBUVB and excimer laser-treated groups when excellent responses (more than 75% repigmentation achieved at 12 weeks) appeared.
The repigmentation patterns according to location, age, duration of lesions, and speed of response showed similarities in both the NBUVB and excimer laser-treated groups.
白癜风可出现多种复色模式，如毛囊周围、边缘、弥漫和混合模式。本研究旨在临床评估窄谱中波紫外线（NBUVB）光疗或使用 308nm 准分子激光进行靶向光疗获得的复色模式类型，并揭示复色模式是否与病变部位、患者年龄、病变持续时间或改善速度有关。
本研究纳入了 51 例 NBUVB 单独治疗有效（与基线相比有应答）的患者和 52 例准分子激光单独治疗有效（与基线相比有应答）的患者。我们评估了治疗出现应答时的复色模式。
NBUVB（42.2%）或准分子激光（51.3%）治疗的两组患者中，最常见的复色模式均为毛囊周围型，其次为边缘型、弥漫型和混合型，依次类推。复色模式与病变部位、患者年龄或病变持续时间无关。在 NBUVB 和准分子激光治疗组中，当出现极好的应答（12 周时达到 75%以上的复色）时，均以边缘型为主。
NBUVB 和准分子激光治疗组的复色模式与位置、年龄、病变持续时间和应答速度有关，这些因素均存在相似性。
