Hori K, Fukuda Y, Tomita T, Kosaka T, Tamura K, Nishigami T, Kubota A, Shimoyama T
Department of Gastroenterology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.
J Clin Pathol. 2003 Aug;56(8):629-30. doi: 10.1136/jcp.56.8.629.
This report describes a case of refractory enteropathy with circulating intestinal goblet cell autoantibodies (IGA). A 19 year old man with hyperthyroidism had suffered from protracted diarrhoea for nearly 10 years. Histological examination showed evidence of collagenous enterocolitis. The diarrhoea did not improve despite fasting under total parenteral nutrition. An immunofluorescence assay demonstrated IGA without anti-enterocyte autoantibodies, the hallmark of autoimmune enteropathy, although other criteria were fulfilled. None of 109 controls, including 55 cases of inflammatory bowel disease and one of lymphocytic colitis, had IGA. This case is considered to be a variant of autoimmune enteropathy, and might be a distinct entity.
本报告描述了一例伴有循环肠道杯状细胞自身抗体（IGA）的难治性肠病。一名患有甲状腺功能亢进的19岁男性长期腹泻近10年。组织学检查显示有胶原性小肠结肠炎的证据。尽管在全胃肠外营养支持下禁食，腹泻仍未改善。免疫荧光检测显示存在IGA，但无抗肠上皮细胞自身抗体，而抗肠上皮细胞自身抗体是自身免疫性肠病的标志，尽管满足了其他标准。109名对照者，包括55例炎症性肠病患者和1例淋巴细胞性结肠炎患者，均未检测到IGA。该病例被认为是自身免疫性肠病的一种变异型，可能是一种独特的疾病实体。
