Hill S M, Milla P J, Bottazzo G F, Mirakian R
Department of Child Health, Institute of Child Health, London.
Gut. 1991 Jan;32(1):36-42. doi: 10.1136/gut.32.1.36.
Children with protracted diarrhoea, circulating enterocyte autoantibodies, and an enteropathy showing features of inappropriate HLA molecule expression on the jejunal crypt epithelium, often present with persistent blood and mucus in their stools. Eight children with autoimmune enteropathy were investigated for the presence of associated colonic disease. Six children with protracted diarrhoea, no circulating autoantibodies, and an enteropathy (in five of them) undergoing colonoscopy were used as control subjects. In all eight patients, but not in the control subjects, there was macroscopic and microscopic evidence of an accompanying colitis of variable severity, thus indicating that a more generalised intestinal disorder was present, which might affect the whole intestine. Aberrant expression of DR molecules on the colonic surface and crypt epithelium was also detected. Autoimmunity may play a role in the colitis.
患有迁延性腹泻、循环肠上皮细胞自身抗体以及空肠隐窝上皮出现不适当HLA分子表达特征的肠病的儿童，其粪便中常持续出现血液和黏液。对8例自身免疫性肠病患儿进行了相关结肠疾病的调查。6例患有迁延性腹泻、无循环自身抗体且（其中5例）接受结肠镜检查的肠病患儿作为对照。在所有8例患者中，但对照患者中未发现，有不同严重程度的伴随结肠炎的宏观和微观证据，这表明存在一种更广泛的肠道疾病，可能会影响整个肠道。还检测到结肠表面和隐窝上皮DR分子的异常表达。自身免疫可能在结肠炎中起作用。
