Acar O, Demirtas M, Kacar S, Vural P, Devecioglu Y, Saroglu M, Culha M, Gökalp A
Department of Urology, Kocaeli University Medical Faculty, Kocaeli, Turkey.
Urol Int. 2003;71(2):211-4. doi: 10.1159/000071850.
The aim of this study was to investigate the outcome of gastrocystoplasty and the effects of selective antral vagotomy (SAV) on the postprandial gastrin secretion from the antrum as well as on the acid secretion from the augmented bladder.
In this study on 12 male pigs, we applied subtotal cystectomy plus gastric augmentation plus SAV to the study group and the same procedure without SAV to the control group. The animals were followed up for 3 months with respect to feeding, weight, and urine output. The urine pH levels and the gastrin levels of the pigs in the two groups were then followed up and compared.
The use of gastric segments in bladder reconstruction was found to be appropriate in terms of both gastric function and urinary system function. Nevertheless, regarding the effect of SAV, the differences between either the urinary pH levels or the gastrin levels of the pigs in the two groups were statistically significant.
Although gastric segments in the bladder reconstruction were found to be appropriate in terms of both gastric function and urinary system function, SAV did not prevent postprandial gastrin secretion and the resulting increase of the urine acidity.
本研究旨在探讨胃囊肿成形术的结果，以及选择性胃窦迷走神经切断术（SAV）对餐后胃窦胃泌素分泌及扩张膀胱酸分泌的影响。
在这项针对12只雄性猪的研究中，我们对研究组施行次全膀胱切除术加胃扩张术加SAV，对对照组施行相同手术但不做SAV。对动物的进食、体重和尿量进行了3个月的随访。然后对两组猪的尿液pH值水平和胃泌素水平进行随访并比较。
从胃功能和泌尿系统功能来看，利用胃段进行膀胱重建是合适的。然而，就SAV的效果而言，两组猪的尿液pH值水平或胃泌素水平之间的差异具有统计学意义。
尽管从胃功能和泌尿系统功能来看，利用胃段进行膀胱重建是合适的，但SAV并不能阻止餐后胃泌素的分泌以及由此导致的尿液酸度增加。
