Lau J L, Richter H M, Fowler J E, Bhatti R, Ray V
Division of Urology, University of Illinois College of Medicine, Chicago.
J Urol. 1990 Feb;143(2):402-6. doi: 10.1016/s0022-5347(17)39974-3.
Distention of the gastric antrum with an alkaline fluid normally results in the secretion of gastrin. Following gastrocystoplasty in humans, however, hypergastrinemia has not been observed. We explored the possibility that a component of urine may suppress antral gastrin activity in the dog. Partial cystectomy and antral transposition to the bladder (ATB) was performed in five animals and antral transposition to the colon (ATC) was performed in five other dogs to serve as a hypergastrinemic controls. At four and eight weeks after surgery the mean serum gastrin levels in the ATC dogs were significantly greater than the mean preoperative levels (p less than 0.05). In contrast, at four and eight weeks after surgery the mean serum gastrin levels in the ATB animals were significantly less than the mean preoperative levels (p less than 0.05). The antral G-cell density as determined by immunohistochemical study at eight weeks after surgery was greater than normal in the ATC dogs but less than normal in the ATB dogs; but the differences did not achieve statistical significance. In another series of experiments using four other dogs a 4% aqueous peptone solution and a 4% peptone solution in concentrated dog urine were instilled into exteriorized antral pouches. The mean serum gastrin levels at 60 and 90 minutes after instillation of the former were significantly increased (p less than 0.05), but there was little or no change after instillation of the latter. Urine, or a component of urine, appears to suppress canine antral gastrin secretion and may explain the absence of hypergastrinemia following gastrocystoplasty in humans.
用碱性液体扩张胃窦通常会导致胃泌素分泌。然而，在人类进行胃囊肿成形术后，并未观察到高胃泌素血症。我们探讨了尿液中的一种成分可能抑制犬胃窦胃泌素活性的可能性。对5只动物进行了部分膀胱切除术并将胃窦移位至膀胱（ATB），对另外5只狗进行了胃窦移位至结肠（ATC），作为高胃泌素血症对照。在手术后4周和8周，ATC组狗的平均血清胃泌素水平显著高于术前平均水平（p<0.05）。相比之下，在手术后4周和8周，ATB组动物的平均血清胃泌素水平显著低于术前平均水平（p<0.05）。术后8周通过免疫组织化学研究确定的胃窦G细胞密度，在ATC组狗中高于正常，但在ATB组狗中低于正常；但差异未达到统计学意义。在另一系列使用另外4只狗的实验中，将4%的蛋白胨水溶液和浓缩犬尿中的4%蛋白胨溶液注入外置的胃窦袋中。注入前者后60分钟和90分钟时的平均血清胃泌素水平显著升高（p<0.05），但注入后者后几乎没有变化。尿液或尿液中的一种成分似乎会抑制犬胃窦胃泌素分泌，这可能解释了人类胃囊肿成形术后无高胃泌素血症的原因。
