Tiffany P, Vaughan E D, Marion D, Amberson J
J Urol. 1986 Sep;136(3):692-5. doi: 10.1016/s0022-5347(17)45029-4.
Antral gastrocystoplasty has been previously described as an effective method of bladder augmentation or replacement. Six dogs underwent gastrocystoplasty. Two bladders were augmented utilizing the gastric fundus, one antral augmentation was performed, and three total bladder replacements were created utilizing the antrum. Each dog was followed for at least twelve months or until death from peptic ulcer disease with periodic evaluation for urinary continence, serum gastrin level, serum electrolytes, urine culture, urine pH and the radiographic appearance of the urinary reservoir and upper tracts. All four dogs with antral gastrocystoplasties developed severe hypergastrinemia and two demonstrated gross ulcers. In contrast, the two dogs with fundic augmentation did not show elevation of serum gastrin levels or evidence of peptic ulcer disease. Severe hypergastrinemia can be expected following antral gastrocystoplasty and the resultant ulcer disease can be fatal.
胃窦膀胱扩大成形术此前已被描述为一种有效的膀胱扩大或替代方法。六只狗接受了胃膀胱扩大成形术。两只狗利用胃底进行膀胱扩大，进行了一例胃窦扩大，三只狗利用胃窦进行了全膀胱替代。每只狗至少随访十二个月，或直至死于消化性溃疡病，并定期评估尿失禁、血清胃泌素水平、血清电解质、尿培养、尿pH值以及储尿囊和上尿路的影像学表现。所有接受胃窦膀胱扩大成形术的四只狗均出现严重高胃泌素血症，两只出现肉眼可见的溃疡。相比之下，两只接受胃底扩大的狗血清胃泌素水平未升高，也没有消化性溃疡病的证据。胃窦膀胱扩大成形术后可预期出现严重高胃泌素血症，由此导致的溃疡病可能是致命的。
