Sperling Robert T, Pinto Duane S, Ho Kalon K L, Carrozza Joseph P
Section of Interventional Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
Catheter Cardiovasc Interv. 2003 Aug;59(4):459-62. doi: 10.1002/ccd.10576.
We report the time course to the restoration of normal platelet aggregation in three patients who were treated with eptifibatide in the setting of severe renal failure. There was prolonged platelet inhibition in the first patient who developed acute renal failure. The second patient with acute on chronic renal failure developed an intracerebral hemorrhage. Normal platelet aggregation was restored after acute hemodialysis. In a third patient with end-stage renal disease, platelet function returned to the normal range following hemodialysis. There is a prolonged time course to the restoration of normal platelet aggregation in patients with severe renal dysfunction who are treated with eptifibatide. Acute renal hemodialysis may reverse the inhibitory effect of eptifibatide on platelet aggregation in these patients.
我们报告了3例在严重肾衰竭情况下接受依替巴肽治疗的患者恢复正常血小板聚集的时间过程。首例发生急性肾衰竭的患者存在血小板抑制时间延长的情况。第二例慢性肾衰竭急性加重的患者发生了脑出血。急性血液透析后血小板聚集恢复正常。第三例终末期肾病患者在血液透析后血小板功能恢复到正常范围。接受依替巴肽治疗的严重肾功能不全患者恢复正常血小板聚集的时间过程较长。急性肾血液透析可能会逆转依替巴肽对这些患者血小板聚集的抑制作用。
