Goodlad R A, Ghatei M A, Bloom S R, Levin S, Wright N A
Histopathology Unit, Imperial Cancer Research Fund, London, UK.
Digestion. 1992;53(1-2):1-7. doi: 10.1159/000200965.
Dogs were given a prostaglandin analogue, misoprostol, at a dose that significantly increases gastrointestinal epithelial cell proliferation. Both basal and postprandial concentrations of gastrin were significantly higher in the misoprostol-treated dogs and more than doubled after the meal in both the controls and in the test group. Plasma enteroglucagon, cholecystokinin, insulin and glucose-dependent insulinotrophic peptide all increased postprandially, with no effect of misoprostol. Tissue concentrations of bombesin, gastrin and somatostatin were unaffected by misoprostol, but the fundic glucagon-like immunoreactivity was significantly increased. Thus high doses of misoprostol have only minor effects on gastrointestinal regulatory peptides, suggesting that the trophic effect of prostaglandins on the intestinal tract may be direct.
给狗服用一种前列腺素类似物米索前列醇，剂量能显著增加胃肠道上皮细胞增殖。米索前列醇治疗组狗的胃泌素基础浓度和餐后浓度均显著高于对照组，且餐后两组的胃泌素浓度均增加了一倍多。血浆肠高血糖素、胆囊收缩素、胰岛素和葡萄糖依赖性促胰岛素多肽餐后均升高，米索前列醇对此无影响。蛙皮素、胃泌素和生长抑素的组织浓度不受米索前列醇影响，但胃底胰高血糖素样免疫反应性显著增加。因此，高剂量米索前列醇对胃肠道调节肽只有轻微影响，提示前列腺素对肠道的营养作用可能是直接的。
