Goodlad R A, Madgwick A J, Moffatt M R, Levin S, Allen J L, Wright N A
Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Gut. 1989 Mar;30(3):316-21. doi: 10.1136/gut.30.3.316.
The effects of the methyl ester analogue of prostaglandin E1, misoprostol, on gastric epithelial cell proliferation were investigated in six dogs given 300 micrograms/kg/day of misoprostol orally for 11 weeks and in six control dogs given placebo for 11 weeks. Misoprostol treatment resulted in a 36% increase in stomach weight (p less than 0.01) and a 30% increase in the length (measured as the cell column count from the base/neck junction to the surface) of the fundic gastric glands (p less than 0.01). This mucosal hyperplasia was predominantly caused by enlargement of the foveolar region of the gland, with little change occurring in the neck or in the isthmus. The hyperplasia was the result of an increased number of mitotic (p less than 0.01) and DNA synthesising cells (p less than 0.05) in each gastric gland, which resulted in a significant increase in the gland cell production rate, from 22.5 to 42.6 cells per gland per day (p less than 0.05).
研究了前列腺素E1甲酯类似物米索前列醇对胃上皮细胞增殖的影响。将6只犬口服给予米索前列醇300微克/千克/天，持续11周，另6只对照犬给予安慰剂11周。米索前列醇治疗导致胃重量增加36%（p<0.01），胃底腺长度（从基部/颈部交界处到表面的细胞柱计数）增加30%（p<0.01）。这种黏膜增生主要是由腺体小凹区域的扩大引起的，颈部或峡部几乎没有变化。增生是由于每个胃腺中有丝分裂细胞数量增加（p<0.01）和DNA合成细胞数量增加（p<0.05），导致腺细胞产生率从每天每个腺体22.5个细胞显著增加到42.6个细胞（p<0.05）。
