Shamsuzzaman A K, Sirajee A, Rahman M, Miah A G, Hossain M A
Microbiology, Mymensingh Medical College, Mymensingh-2200, Bangladesh.
Mymensingh Med J. 2003 Jul;12(2):98-103.
The pattern of aerobic bacteria with their antibiotic susceptibility isolated from infected patients in one of the surgical units at Mymensingh Medical College Hospital during the period from September to November' 2000 were reported in the present study. Out of 74 clinical samples, 52 were wound swabs, 18 were pus and 4 were urine. Bacterial growth was yielded in 43 samples and the distribution of isolates was as follows: Pseudomonas spp 16, Esch.coli 13, Staphylococcus aureus 08, Klebsiella spp. 03 and others 03. Majority (61.5 %) of culture positive results were found in wound swabs. Antibiotic susceptibility pattern showed considerable variation within Gram negative bacterial isolates. All the Esch.coli and Klebsiella isolates were resistant to amoxicillin. Ceftriaxone (65.6% and 100% respectively) and ciprofloxacin (71.4% and 100%) still appeared to be highly sensitive for both species. Over 93% strains of Pseudomonas were sensitive to Ceftazidime and aztreonam. Whereas, over 43% of same strains were resistant to ciprofloxacin. Over 87% strains of Staph.aureus were resistant to penicillin but sensitive to erythromycin. Whereas, 100% of those strains were sensitive to cloxacillin. Over 50% of all isolates were sensitive to gentamicin but resistant to cefalexin and cotrimoxazole. It was suggested to be careful regarding selection of antibiotic regime in surgical cases to minimize incoming higher magnitude of drug resistance among bacteria in near future.
本研究报告了2000年9月至11月期间从迈门辛医学院医院某外科病房感染患者中分离出的需氧菌及其抗生素敏感性模式。在74份临床样本中，52份是伤口拭子，18份是脓液，4份是尿液。43份样本中培养出细菌，分离菌株的分布如下：假单胞菌属16株、大肠杆菌13株、金黄色葡萄球菌8株、克雷伯菌属3株和其他3株。大部分（61.5%）培养阳性结果来自伤口拭子。抗生素敏感性模式在革兰氏阴性菌分离株中显示出相当大的差异。所有大肠杆菌和克雷伯菌分离株对阿莫西林耐药。头孢曲松（分别为65.6%和100%）和环丙沙星（71.4%和100%）对这两种菌仍表现出高度敏感性。超过93%的假单胞菌菌株对头孢他啶和氨曲南敏感。然而，超过43%的相同菌株对环丙沙星耐药。超过87%的金黄色葡萄球菌菌株对青霉素耐药，但对红霉素敏感。然而，这些菌株中有100%对氯唑西林敏感。超过50%的所有分离株对庆大霉素敏感，但对头孢氨苄和复方新诺明耐药。建议在外科病例中谨慎选择抗生素治疗方案，以尽量减少近期细菌中耐药性增加的情况。
