Borrowman Theresa A, Lutz Michael E, Walsh John S
Deparment of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
J Am Acad Dermatol. 2003 Aug;49(2):307-10. doi: 10.1067/s0190-9622(03)00433-x.
We report a unique case of a 69-year-old man who presented with a 1-year history of pink nodules and plaques limited to the anterior plantar surface of the right foot and a 30-year history of a callus on the right heel. Histologic examination findings of both areas showed deposits of amorphous, eosinophilic material and an infiltrate of plasma cells in the dermis. Congo red-stained deposits exhibited apple-green birefringence with polarized light. Results of an extensive clinical and laboratory evaluation showed no evidence of systemic amyloidosis. The diagnosis of nodular primary localized cutaneous amyloidosis (PLCA) was made. Nodular PLCA isolated to pedal or strictly plantar surfaces is an unusual presentation of PLCA. The origin and the clinical and histopathologic features of nodular PLCA are reviewed.
我们报告了一例独特病例，患者为69岁男性，右脚足底前部出现粉红色结节和斑块1年，右脚跟部有胼胝30年。这两个部位的组织学检查结果显示真皮中有无定形嗜酸性物质沉积和浆细胞浸润。刚果红染色沉积物在偏振光下呈现苹果绿双折射。广泛的临床和实验室评估结果显示无系统性淀粉样变性证据。诊断为结节性原发性局限性皮肤淀粉样变性（PLCA）。局限于足部或严格足底表面的结节性PLCA是PLCA的一种不寻常表现。本文对结节性PLCA的起源以及临床和组织病理学特征进行了综述。
