新生儿落叶型天疱疮

Neonatal pemphigus foliaceus.

作者信息

Hirsch Ranella, Anderson Judy, Weinberg Jeffrey M, Burnstein Penina, Echt Audrey, Fermin Janet, Heilman Edward R, Laude Teresita A

机构信息

Department of Dermatology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY, USA.

出版信息

J Am Acad Dermatol. 2003 Aug;49(2 Suppl Case Reports):S187-9. doi: 10.1067/mjd.2003.339.

DOI:10.1067/mjd.2003.339

PMID:12894119

Abstract

The term "pemphigus" refers to a group of diseases that are characterized by the presence of cutaneous or mucosal blisters and erosions, and antiepidermal autoantibodies. There are several case reports of neonatal pemphigus vulgaris in the literature. Although pemphigus foliaceus antibodies have been shown to cross the placenta, to our knowledge, this is only the second reported case of neonatal pemphigus foliaceus. The proposed mechanism of disease transfer is the passive transfer of maternal IgG antibodies across the placenta.

摘要

“天疱疮”一词指的是一组以皮肤或黏膜水疱及糜烂以及抗表皮自身抗体为特征的疾病。文献中有几例新生儿寻常型天疱疮的病例报告。尽管落叶型天疱疮抗体已被证明可穿过胎盘，但据我们所知，这仅是第二例报告的新生儿落叶型天疱疮病例。推测的疾病传播机制是母体IgG抗体经胎盘被动转移。