Mills Gordon B, Moolenaar Wouter H
MD Anderson Cancer Center, Houston, Texas 77030, USA.
Nat Rev Cancer. 2003 Aug;3(8):582-91. doi: 10.1038/nrc1143.
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.
生物活性磷脂溶血磷脂酸（LPA）通过作用于其同源G蛋白偶联受体来刺激细胞增殖、迁移和存活。LPA的异常产生、受体表达和信号传导可能促成癌症的起始、进展和转移。最近对介导LPA产生和降解的胞外酶的鉴定以及受体选择性类似物的开发，揭示了可通过这些机制调节LPA的产生或作用以用于癌症治疗。
