Lamprecht Sergio A, Lipkin Martin
Strang Cancer Prevention Center and Strang Cancer Research Laboratory at The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.
Nat Rev Cancer. 2003 Aug;3(8):601-14. doi: 10.1038/nrc1144.
Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.
最近的研究结果表明，膳食钙、维生素D和叶酸可以调节和抑制结肠癌的发生。从各种各样的临床前实验研究、流行病学研究结果以及一些人体临床试验中都获得了支持证据。本文讨论了这些微量营养素有助于其肿瘤调节作用的重要分子事件和细胞作用。它们包括一系列复杂的信号事件，这些事件会影响结肠细胞的结构和功能组织。
