Wang Yanping, Tao Meihui, Wang Li, Zhou Siyu, Yang Weifeng, Zhao Xi, Feng Qinyu, Tang Mengfan, Yan Wei, Fu Yu
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Nutr. 2025 Jul 9;12:1594656. doi: 10.3389/fnut.2025.1594656. eCollection 2025.
Calcium, a vital nutrient for the human body, is indispensable for keeping our bones strong and managing cell function. A diet low in calcium (DLC) is a key player in the formation of numerous health issues. This research delved into the most recent datasets acquired via the 2021 Global Burden of Disease (GBD) report to uncover the worldwide impact of DLC.
Utilizing the GBD 2021 database, this research examined the association of DLC with disease burden, covering colorectal and prostate cancers. To quantify disease burden and track its temporal variations, key indicators were employed. These included deaths, disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR), age-standardized DALY rate (ASDR), and the estimated annual percentage change (EAPC). The analysis broke down results by sex, age brackets, Socio-demographic Index (SDI) categories, and geographic regions. To examine potential links between disease burden and socioeconomic factors, Pearson's correlation method was applied. Furthermore, Bayesian age-period-cohort (BAPC) modeling was applied to forecast trends spanning 2022-2050.
From 1990 to 2021, global colon and rectum cancer (CRC)-related deaths tied to DLC rose from 57,363 to 89,089, while the ASMR decreased from 1.54 to 1.06 per 100,000 [EAPC = -1.33 (95% CI: -1.37 to -1.29)]. DALYs increased from 1,512,762 to 2,128,939, and the ASDR declined from 37.04 to 24.7 per 100,000 [EAPC = -1.45 (95% CI: -1.50 to -1.40)]. The burden of CRC tended to escalate with age, and it disproportionately affected women more than men. However, the impact on women diminished more rapidly over time. Prostate cancer and DLC showed a negative directional trend but lacked statistical significance. CRC burden showed a negative correlation with SDI, while prostate cancer burden had a positive association.
DLC significantly increases the incidence of CRC, while its impact on prostate cancer incidence is relatively minor and shows a negative correlation. Both phenomena are closely associated with socioeconomic development. The research yields essential data to develop focused dietary interventions and cancer-prevention policies.
钙是人体必需的营养素，对于保持骨骼强健和维持细胞功能不可或缺。低钙饮食（DLC）是引发众多健康问题的关键因素。本研究深入探讨了通过《2021年全球疾病负担（GBD）报告》获取的最新数据集，以揭示DLC对全球的影响。
利用GBD 2021数据库，本研究考察了DLC与疾病负担之间的关联，涵盖结直肠癌和前列腺癌。为了量化疾病负担并追踪其随时间的变化，采用了关键指标。这些指标包括死亡人数、伤残调整生命年（DALYs）、年龄标准化死亡率（ASMR）、年龄标准化DALY率（ASDR）以及估计年变化百分比（EAPC）。分析按性别、年龄组、社会人口指数（SDI）类别和地理区域对结果进行了分类。为了检验疾病负担与社会经济因素之间的潜在联系，应用了Pearson相关方法。此外，应用贝叶斯年龄-时期-队列（BAPC）模型预测了2022年至2050年的趋势。
1990年至2021年，全球与DLC相关的结肠直肠癌（CRC）死亡人数从57363人增至89089人，而ASMR从每10万人1.54例降至1.06例[EAPC = -1.33（95%CI：-1.37至-1.29）]。DALYs从1512762增至2128939，ASDR从每10万人37.04例降至24.7例[EAPC = -1.45（95%CI：-1.50至-1.40）]。CRC的负担往往随着年龄的增长而增加，而且对女性的影响比对男性更大。然而，随着时间的推移，对女性的影响下降得更快。前列腺癌与DLC呈负向趋势，但缺乏统计学意义。CRC负担与SDI呈负相关，而前列腺癌负担呈正相关。
DLC显著增加CRC的发病率，而其对前列腺癌发病率的影响相对较小且呈负相关。这两种现象均与社会经济发展密切相关。该研究产生了重要数据，有助于制定针对性的饮食干预措施和癌症预防政策。
