Tobler K, Ackermann M, Griot C
Virologisches Institut, Universität Zürich, Mittelhäusern.
Schweiz Arch Tierheilkd. 2003 Jul;145(7):316-22. doi: 10.1024/0036-7281.145.7.316.
Severe acute respiratory syndrome (SARS) is an emerging disease, which was first recognized in Guangdong Province, China, in November 2002. In the meantime, SARS has been recognized in patients on all five continents. A novel coronavirus, which is not related to the hitherto known coronaviruses, has been proven to be associated with the disease. Our genomic analyses strongly suggest that the new SARS-coronavirus did not emerge through mutation or recombination and that it has probably been transmitted from a so far not identified animal species to humans. Therefore, it is most likely that SARS virus is a zoonotic agent. A broad body of knowledge originating from research in veterinary medicine indicates that development of vaccines against the SARS-coronavirus may be problematic. The potential danger of such vaccines should not be neglected during the process of vaccine development.
严重急性呼吸综合征（SARS）是一种新出现的疾病，2002年11月在中国广东省首次被发现。与此同时，五大洲的患者中都出现了SARS病例。一种新型冠状病毒，与迄今已知的冠状病毒无关，已被证实与该疾病有关。我们的基因组分析强烈表明，新的SARS冠状病毒并非通过突变或重组产生，很可能是从一种尚未确定的动物物种传播给人类的。因此，SARS病毒很可能是一种人畜共患病原体。来自兽医学研究的大量知识表明，研发针对SARS冠状病毒的疫苗可能存在问题。在疫苗研发过程中，此类疫苗的潜在风险不容忽视。
