Bluth R, Pinkert R, Steger E
Zahn Mund Kieferheilkd Zentralbl. 1975;63(7):680-6.
Positive clinical results were obtained using implanted cold polymerizates, and these were compared with the negative results of experiments made on animals. The observed local pathophysiological processes are considered to be due to the effects produced by the methacrylic methyl ester. The absolute content of residual monomers in the implants does not allow to make any definite conclusions as to the rate of diffusion into the organism. Therefore, the diffusion of residual monomers into an aqueous medium was titrimetrically measured for three weeks by the pyridine sulfate dibromide method. After a description of the method of titration and the results obtained, a discussion is given of the causes of the different rates of diffusion of residual monomers from Kallokryl K and Palacos samples, which are dependent upon the duration of polymerization in air.
使用植入的冷聚合体获得了积极的临床结果，并将这些结果与在动物身上进行的实验的阴性结果进行了比较。观察到的局部病理生理过程被认为是由于甲基丙烯酸甲酯产生的影响。植入物中残留单体的绝对含量无法就其向生物体扩散的速率得出任何明确结论。因此，通过硫酸吡啶二溴化物法用滴定法测量了残留单体在三周内扩散到水介质中的情况。在描述了滴定方法和所得结果之后，讨论了Kallokryl K和Palacos样品中残留单体扩散速率不同的原因，这些原因取决于在空气中的聚合持续时间。
