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细菌对抗生素耐药性的介电电泳测定

Dielectrophoretic assay of bacterial resistance to antibiotics.

作者信息

Johari Juliana, Hübner Yvonne, Hull Judith C, Dale Jeremy W, Hughes Michael P

机构信息

School of Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

出版信息

Phys Med Biol. 2003 Jul 21;48(14):N193-8. doi: 10.1088/0031-9155/48/14/401.

Abstract

The dielectrophoretic collection spectra of antibiotic-sensitive and antibiotic-resistant strains of Staphylococcus epidermidis have been determined. These indicate that in the absence of antibiotic treatment there is a strong similarity between the dielectric properties of sensitive and resistant strains, and that there is a significant difference between the sensitive strains before and after treatment with the antibiotic streptomycin after 24 h exposure. This method offers possibilities for the assessment of bacterial resistance to antibiotics.

摘要

已测定了表皮葡萄球菌抗生素敏感菌株和抗生素耐药菌株的介电泳收集光谱。这些结果表明,在未进行抗生素治疗时,敏感菌株和耐药菌株的介电特性有很强的相似性,并且在暴露于抗生素链霉素24小时后,敏感菌株在治疗前后存在显著差异。该方法为评估细菌对抗生素的耐药性提供了可能性。

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