He Haiyin, Janso Jeffrey E, Williamson R Thomas, Yang Hui Y, Carter Guy T
Natural Products Research, Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA.
J Org Chem. 2003 Aug 8;68(16):6079-82. doi: 10.1021/jo030067f.
Cytosporacin (1), a novel antibacterial polyketide containing naphthopyranone and isochromandione moieties, was isolated from the fermentation broth of the fungus Cytospora rhizophorae. A (1)H-detected ACCORD-ADEQUATE pulse sequence that distinguished (2)J(CH) from (3)J(CH) correlations provided critical information for structural determination. NOE studies established the relative configuration and revealed the presence of two rotamers. A biosynthetic (13)C-labeling experiment indicated that cytosporacin was derived from acetate origin.
胞孢菌素（1）是一种含有萘并吡喃酮和异色满二酮部分的新型抗菌聚酮化合物，从真菌根腐壳囊孢的发酵液中分离得到。一种通过¹H检测的ACCORD - ADEQUATE脉冲序列，该序列能够区分²J(CH)和³J(CH)相关，为结构测定提供了关键信息。NOE研究确定了相对构型，并揭示了存在两种旋转异构体。一项生物合成¹³C标记实验表明胞孢菌素来源于乙酸盐。
