真菌属 Ehrenb.（子囊菌门）中的生物活性次生代谢产物。

Bioactive Secondary Metabolites from Fungi of the Genus Ehrenb. (Ascomycota).

机构信息

Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon.

Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde P.O. Box 812, Cameroon.

出版信息

Molecules. 2023 Mar 31;28(7):3120. doi: 10.3390/molecules28073120.

DOI:10.3390/molecules28073120

PMID:37049883

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10096137/

Abstract

is a genus of fungi belonging to the Cytosporaceae family (Sordariomycetes, Ascomycota) considered as a prolific source of specialized metabolites due to their ability to produce diverse secondary metabolites with a broad range of biological activities. Since the first chemical investigation of this genus in the 1980s, further studies have led to the isolation and structural elucidation of several bioactive compounds including cytosporones, nonanolides, macrocyclic dilactones, and terpenoids. This review summarizes, for the first time, the chemical diversity of bioactive secondary metabolites from the genus and highlights its potential as an alternative source of secondary metabolites for pharmacological studies. Moreover, this review will serve as a basis for future investigations of compounds of this genus.

摘要

是属于 Cytosporaceae 科（Sordariomycetes，Ascomycota）的真菌属，由于其能够产生具有广泛生物活性的多种次生代谢物，被认为是专门代谢物的丰富来源。自 20 世纪 80 年代首次对该属进行化学研究以来，进一步的研究导致了几种生物活性化合物的分离和结构阐明，包括细胞酮、壬内酯、大环二内酯和萜类化合物。这篇综述首次总结了属中生物活性次生代谢物的化学多样性，并强调了它作为药理学研究中次生代谢物替代来源的潜力。此外，这篇综述将为该属化合物的未来研究提供基础。