Weller Richard
Systems Group, Department of Dermatology, University of Edinburgh, Lauriston Building, Lauriston Place, Edinburgh EH3 9HA, Scotland, UK.
Clin Sci (Lond). 2003 Nov;105(5):533-5. doi: 10.1042/CS20030241.
Nitric oxide (NO) is involved in several processes in the skin, including wound healing, pigmentation and regulation of apoptosis. Pharmacological intervention with NO donors appears to be a promising treatment for conditions such as diabetic ulceration. In this issue of Clinical Science, Khan et al. describe the synthesis of a number of NO donors, based on nitrosylated thiosugars, structural changes in which altered the rate of NO release. The in vivo behaviour of one of the donors was then measured by laser Doppler blood flow measurements on the skin. The ability to tailor the pharmacokinetic behaviour of these drugs should be of interest in developing NO donors for clinical use.
一氧化氮（NO）参与皮肤中的多个过程，包括伤口愈合、色素沉着和细胞凋亡调节。使用NO供体进行药物干预似乎是治疗糖尿病溃疡等病症的一种有前景的方法。在本期《临床科学》中，汗等人描述了基于亚硝基化硫糖合成的多种NO供体，其结构变化改变了NO的释放速率。然后通过对皮肤进行激光多普勒血流测量来测定其中一种供体的体内行为。在开发用于临床的NO供体时，调整这些药物药代动力学行为的能力应该会引起人们的兴趣。
