Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea.
J Control Release. 2015 Dec 28;220(Pt B):624-30. doi: 10.1016/j.jconrel.2015.08.057. Epub 2015 Sep 5.
This work demonstrates the development of nitric oxide-releasing ointment and its potential on efficient wound healing. Nitric oxide-releasing polymer was successfully synthesized, which is composed of biocompatible Pluronic F127, branched polyethylenimine and 1-substituted diazen-1-ium-1,2-diolates. The synthesized nitric oxide-releasing polymer was incorporated into the PEG-based ointment which not only facilitated nitric oxide release in a slow manner, but also served as a moisturizer to enhance the wound healing. As compared to control groups, the nitric oxide-releasing ointment showed the accelerated wound closure with enhanced re-epithelialization, collagen deposition, and blood vessel formation in vivo. Therefore, this nitric oxide-based ointment presents the promising potential for the efficient strategy to heal the cutaneous wound.
本工作展示了一氧化氮释放软膏的开发及其在高效伤口愈合方面的潜力。成功合成了由生物相容性 Pluronic F127、支化聚乙烯亚胺和 1-取代重氮-1,2-二醇盐组成的一氧化氮释放聚合物。将合成的一氧化氮释放聚合物掺入基于 PEG 的软膏中，不仅可以缓慢释放一氧化氮，还可以作为保湿剂来增强伤口愈合。与对照组相比，释放一氧化氮的软膏在体内表现出加速的伤口闭合，增强了再上皮化、胶原蛋白沉积和血管形成。因此，这种基于一氧化氮的软膏为高效治疗皮肤伤口的策略提供了有前途的潜力。
