Trentham-Dietz A, Remington P L, Moinpour C M, Hampton J M, Sapp A L, Newcomb P A
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53726, USA.
Oncologist. 2003;8(4):342-9. doi: 10.1634/theoncologist.8-4-342.
Although the number of women who survive treatment for colorectal cancer is growing, little is known about the quality of life of long-term survivors. The purpose of analyses presented in this paper is to describe the overall health-related quality of life of female long-term colorectal cancer survivors and the factors that may modify their levels of quality of life. A population-based sample of 726 Wisconsin women diagnosed with colorectal cancer from 1990-1991 was recontacted. Of the 443 women alive in 1999, 307 (69%) completed a follow-up questionnaire including the Medical Outcomes Study Short-Form 36 Health Status Survey, which is comprised of 36 items that generate nine domain scale scores and two summary scores: the Physical Component Summary score and the Mental Component Summary score. The mean follow-up was 9 years (range 7-11), and the mean age at follow-up was 72 years (range 43-85). The mean Physical Component Summary score was lower for participants with greater ages, greater numbers of comorbidities, and greater body masses at the time of follow-up. The mean Mental Component Summary score also was lower for participants with greater numbers of comorbidities. Differences associated with degree of comorbidity were observed for all eight domain scales. Female long-term survivors of colorectal cancer appear to report health-related quality of life comparable with that of similarly aged women in the general population. These data suggest that, over the long term, factors attributable to aging, body weight, and chronic medical conditions play more dominant roles in determining physical and mental health than factors related to the initial colorectal cancer diagnosis.
尽管接受结直肠癌治疗后存活下来的女性人数在不断增加，但对于长期幸存者的生活质量却知之甚少。本文所呈现的分析目的是描述女性结直肠癌长期幸存者与健康相关的总体生活质量，以及可能影响其生活质量水平的因素。我们再次联系了1990年至1991年期间在威斯康星州被诊断患有结直肠癌的726名女性组成的基于人群的样本。在1999年仍在世的443名女性中，有307名（69%）完成了一份随访问卷，其中包括医学结局研究简版36项健康状况调查问卷，该问卷由36个项目组成，可生成九个领域量表得分和两个总结得分：身体成分总结得分和心理成分总结得分。平均随访时间为9年（范围7 - 11年），随访时的平均年龄为72岁（范围43 - 85岁）。随访时年龄较大、合并症数量较多以及体重较大的参与者，其平均身体成分总结得分较低。合并症数量较多的参与者，其平均心理成分总结得分也较低。在所有八个领域量表中均观察到与合并症程度相关的差异。结直肠癌女性长期幸存者报告的与健康相关的生活质量似乎与一般人群中年龄相仿的女性相当。这些数据表明，从长期来看，衰老、体重和慢性疾病等因素在决定身心健康方面比与最初的结直肠癌诊断相关的因素发挥着更主要的作用。
