Wallach Corey J, Gilbertson Lars G, Kang James D
Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Spine (Phila Pa 1976). 2003 Aug 1;28(15 Suppl):S93-8. doi: 10.1097/01.BRS.0000076905.31596.DF.
Review of current approaches to gene therapy as a potential treatment modality for regeneration of the degenerating intervertebral disc.
Describe recent advances in the field of gene therapy pertaining to treatment of the degenerating intervertebral disc.
The potential application of gene therapy to the treatment of degenerative disc disease has been an area of exciting and active research. Several in vitro studies have documented the capacity of gene therapy to favorably modify the biologic functions of the intervertebral disc cells with the delivery of the cDNA for various growth factors, whereas in vivo studies have reinforced this potential in animal models. Currently, investigators are exploring the therapeutic potential of gene delivery of the cDNA for several promising factors.
Literature review.
RESULTS/CONCLUSIONS: The application of gene therapy to the treatment of the degenerating intervertebral disc holds much clinical promise and continues to expand as an area of active research. The therapeutic potential of multiple agents, as well as possible vectors, are currently being investigated with encouraging results.
回顾基因治疗作为退变椎间盘再生潜在治疗方式的当前方法。
描述基因治疗领域中与退变椎间盘治疗相关的近期进展。
基因治疗在退行性椎间盘疾病治疗中的潜在应用一直是一个令人兴奋且活跃的研究领域。多项体外研究已证明，通过递送各种生长因子的互补DNA（cDNA），基因治疗能够有利地改变椎间盘细胞的生物学功能，而体内研究在动物模型中也证实了这种潜力。目前，研究人员正在探索几种有前景的因子的cDNA基因递送的治疗潜力。
文献综述。
结果/结论：基因治疗在退变椎间盘治疗中的应用具有很大的临床前景，并且作为一个活跃的研究领域仍在不断扩展。目前正在研究多种药物以及可能的载体的治疗潜力，结果令人鼓舞。
