Wang S Z, Rui Y F, Lu J, Wang C
Department of Orthopaedics, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, 210009, China.
Cell Prolif. 2014 Oct;47(5):381-90. doi: 10.1111/cpr.12121. Epub 2014 Aug 11.
Intervertebral disc degeneration (IDD) is a chronic, complex process associated with low back pain; mechanisms of its occurrence have not yet been fully elucidated. Its process is not only accompanied by morphological changes, but also by systematic changes in its histological and biochemical properties. Many cellular and molecular mechanisms have been reported to be related with IDD and to reverse degenerative trends, abnormal conditions of the living cells and altered cell phenotypes would need to be restored. Promising biological therapeutic strategies still rely on injection of active substances, gene therapy and cell transplantation. With advanced study of tissue engineering protocols based on cell therapy, combined use of seeding cells, bio-active substances and bio-compatible materials, are promising for IDD regeneration. Recently reported progenitor cells within discs themselves also hold prospects for future IDD studies. This article describes the background of IDD, current understanding and implications of potential therapeutic strategies.
椎间盘退变（IDD）是一种与腰痛相关的慢性复杂过程；其发生机制尚未完全阐明。该过程不仅伴随着形态学变化，还伴随着组织学和生化特性的系统性改变。据报道，许多细胞和分子机制与IDD相关，若要逆转退变趋势，需要恢复活细胞的异常状态并改变细胞表型。有前景的生物治疗策略仍依赖于活性物质注射、基因治疗和细胞移植。随着基于细胞治疗的组织工程方案的深入研究，种子细胞、生物活性物质和生物相容性材料的联合应用有望实现IDD再生。最近报道的椎间盘内的祖细胞也为未来的IDD研究带来了希望。本文介绍了IDD的背景、对潜在治疗策略的当前认识及意义。
