Phillips Frank M, An Howard, Kang James D, Boden Scott D, Weinstein James
Spine (Phila Pa 1976). 2003 Aug 1;28(15 Suppl):S99. doi: 10.1097/01.BRS.0000076906.82028.03.
In past decades, the biomechanics of intervertebral disc degeneration have received much attention. More recent research efforts have focused on understanding the biology of the disc degenerative process. The ability to manipulate disc architecture and biology by direct application of growth factors or by gene therapy techniques may present an opportunity to halt or slow disc degeneration. Preliminary studies using these strategies have confirmed their ability to replenish essential disc matrix components that are known to decrease with disc degeneration.
在过去几十年中，椎间盘退变的生物力学受到了广泛关注。最近的研究工作集中在理解椎间盘退变过程的生物学机制上。通过直接应用生长因子或基因治疗技术来操控椎间盘结构和生物学特性，可能为阻止或减缓椎间盘退变提供契机。使用这些策略的初步研究已证实它们能够补充已知会随着椎间盘退变而减少的重要椎间盘基质成分。
