Anderson D Greg, Tannoury Chadi
Department of Orthopaedics, Thomas Jefferson University, Rothman Institute, 925 Chestnut Street, Philadelphia, PA 19107, USA.
Spine J. 2005 Nov-Dec;5(6 Suppl):260S-266S. doi: 10.1016/j.spinee.2005.02.010.
Although symptomatic disc degeneration is thought to be the leading cause of chronic low back pain, no available biologic therapy is yet available to treat this highly prevalent condition.
In this article, the cellular, biomechanical and molecular alterations that occur during disc degeneration are reviewed to provide a better understanding of this pathologic process.
The cellular and molecular aspects of disc degeneration are reviewed.
The available studies detailing the molecular and cellular changes during disc degeneration are reviewed in an effort to provide a basis for understanding the biologic strategies for disc repair.
Disc degeneration begins early in life and involves a cascade of changes at the cellular and molecular level that results in degradation of the extracellular matrix of the disc, leading to biomechanical failure of this complex structure.
With a thorough understanding of the cellular and molecular events causing degeneration of the intervertebral disc, rational strategies for disc repair can be understood and evaluated. It appears that biologic disc repair will be feasible in the future although challenges remain in this blossoming field.
尽管有症状的椎间盘退变被认为是慢性下腰痛的主要原因，但目前尚无可用的生物疗法来治疗这种高度普遍的病症。
本文回顾了椎间盘退变过程中发生的细胞、生物力学和分子改变，以更好地理解这一病理过程。
对椎间盘退变的细胞和分子方面进行综述。
回顾了现有的详细描述椎间盘退变过程中分子和细胞变化的研究，以便为理解椎间盘修复的生物学策略提供依据。
椎间盘退变在生命早期就开始了，涉及细胞和分子水平的一系列变化，导致椎间盘细胞外基质降解，进而导致这个复杂结构的生物力学失效。
通过深入了解导致椎间盘退变的细胞和分子事件，可以理解和评估合理的椎间盘修复策略。虽然在这个蓬勃发展的领域仍存在挑战，但生物椎间盘修复在未来似乎是可行的。
