Matos Elena, Loria Dora, Amestoy Gustavo M, Herrera Lily, Prince Miguel A, Moreno Juan, Krunfly Cristina, van den Brule A J C, Meijer Chris J L M, Muñoz Nubia, Herrero Rolando
Instituto Roffo, University of Buenos Aires and CONICET, Buenos Aires, Argentina.
Sex Transm Dis. 2003 Aug;30(8):593-9. doi: 10.1097/01.OLQ.0000085181.25063.6C.
Preparing for HPV vaccine programs, studies are needed of HPV infection in different populations.
The goal was to evaluate HPV prevalence and determinants in Concordia, Argentina.
A stratified random sample of 1786 households was obtained. Consenting women aged > or =15 years were interviewed and underwent examination, including colposcopy. Cells were collected for a Papanicolaou smear and HPV DNA testing with GP5+/6+ primer-mediated PCR-EIA.
PCR was performed on specimens from 987 women. Prevalence among women reporting no previous sexual activity was 3%, and among sexually active women it was 17.7%, peaking at <25 years of age and decreasing to a minimum at > or =65 years of age. However, low-risk types had similar prevalence (approximately 5%) in all age groups. HPV16 (4.0%), HPV35 (2.6%), and other high-risk types were the most common. Almost half of infections were multiple. Younger women initiated sexual activity earlier and had more partners. The main determinants of HPV detection were lifetime number of sex partners and vaginal discharge.
A clear pattern of decreasing prevalence of HPV with age was observed. This could be explained by development of immunity against specific types over time or related to a cohort effect associated with a recent spread of HPV in this population after recent changes in sexual behavior.
为准备人乳头瘤病毒（HPV）疫苗接种计划，需要对不同人群中的HPV感染情况进行研究。
旨在评估阿根廷康科迪亚市HPV的流行情况及其决定因素。
获取了1786户家庭的分层随机样本。对年龄≥15岁且同意参与的女性进行访谈并进行检查，包括阴道镜检查。采集细胞样本用于巴氏涂片检查以及使用GP5+/6+引物介导的聚合酶链反应-酶免疫测定法（PCR-EIA）进行HPV DNA检测。
对987名女性的样本进行了PCR检测。报告无既往性行为的女性中HPV感染率为3%，有性行为的女性中感染率为17.7%，在年龄＜25岁时达到峰值，在年龄≥65岁时降至最低。然而，低危型HPV在所有年龄组中的感染率相似（约5%）。HPV16（4.0%）、HPV35（2.6%）和其他高危型最为常见。几乎一半的感染为多重感染。年轻女性开始性行为的时间更早且性伴侣更多。HPV检测的主要决定因素是性伴侣的终生数量和白带。
观察到HPV感染率随年龄增长呈明显下降趋势。这可能是由于随着时间推移针对特定类型产生了免疫力，或者与性行为近期变化后该人群中HPV近期传播相关的队列效应有关。
